The CRISPR/Cas9 system, unlike previous genome editing methods that used protein-DNA interactions to mediate sequence recognition, uses an RNA molecule to mediate binding. Recently, a more flexible genome editing technique, CRISPRs linked with HNH domain protein Cas9, promises efficient, long-term safety cancer treatment. Still, their efficacy was limited due to the inability to target epigenetic modification that arises in tumorigenesis. Äifferent genomic engineering tools have been performed in cancer therapy such as ZFNs and TALENs by targeting DNA domain-binding proteins. Additionally, this method is used to make valuable decisions relating to patient therapeutic options. The use of an integrated strategy that incorporates genomic and transcriptomic advancements can provide a comprehensive view of an individual’s genome. The most recent advancements in sequencing technology have made it possible to study the cancer genome more effectively and at a lower cost than ever before. Therefore, developing innovative anti-cancer therapies with less side effects needs a comprehensive understanding of cancer biology. ![]() ![]() Unfortunately, chemotherapy and radiotherapy, the two gold stones in cancer treatment, are also painful for patients and cause severe side effects. At the same time, advancements have been achieved in the prevention and therapeutic approaches, resulting in longer lifetimes or even cures for certain patients with cancer. Cancer is one of the leading causes of disease-related death, increasing worldwide incidence.
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